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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-IDX899
IDX899

Chemical Structure : IDX899

CAS No.: 1018450-26-4

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IDX899 (IDX-899;IDX 899;Fosdevirine;GSK 2248761)

货号: PC-60468Not For Human Use, Lab Use Only.

IDX899 (Fosdevirine, GSK 2248761) is a novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IDX899 (Fosdevirine, GSK 2248761) is a novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.
    IDX899 (Fosdevirine, GSK 2248761) shows substantial benefits in term of HIV mutant activities, physicochemical properties and pharmacological profile.

    物理化学性质&存储条件

    分子量 413.798
    分子式 C20H17ClN3O3P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloro-3-[[3-[(E)-2-cyanovinyl]-5-methyl-phenyl]-(R)-methoxy-phosphoryl]-1H-indole-2-carboxamide

    参考文献

    1. Dousson C, et al. J Med Chem. 2016 Mar 10;59(5):1891-8.

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