IDX-375 | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : IDX-375

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IDX-375 (IDX375)

货号: PC-62828Not For Human Use, Lab Use Only.

IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.

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生物&药学活性

IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.
IDX-375 has no activity against human cellular polymerases (>75 uM).
IDX-375 has an EC50 of 3 nM in HCV replicon luciferase assay.
IDX-375 displays excellent antiviral activity on the genotypes 1a and 1b, and a good PK profile in multiple animal models.

物理化学性质&存储条件

分子量	643.78
分子式	C29H50N5O7PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-N,N,N-trimethylethan-1-aminium 2-(tert-butyl)-1-(3,3-dimethylbutyl)-4-(1-(2-hydroxyethyl)-7-(methylsulfonamido)-1-oxido-4H-benzo[c][1,5,2]diazaphosphinin-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-olate

参考文献

1. Paparin JL, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2634-2640.

2. de Bruijne J, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4525-8.

IDX-375 (IDX375)

生物&药学活性

物理化学性质&存储条件

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IDX-375 (IDX375)

生物&药学活性

物理化学性质&存储条件

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