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首页-小分子抑制剂&激动剂-GPCR-Adenosine Receptor-IDPU
IDPU

Chemical Structure : IDPU

CAS No.: 1215299-86-7

IDPU

货号: PC-26034Not For Human Use, Lab Use Only.

IDPU is a high potent, selective Adenosine A2A receptor (A2AR) antagonist with Ki of 0.0038 nM, has 737-fold selectivity over A1R.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IDPU is a high potent, selective Adenosine A2A receptor (A2AR) antagonist with Ki of 0.0038 nM, has 737-fold selectivity over A1R.
IDPU attenuates haloperidol induced Parkinson like symptoms in rats.
IDPU successfully restores hypo-locomotion induced by haloperidol and NECA.
IDPU also displays protective effect against oxidative stress induced by chronic haloperidol treatment in rats.

物理化学性质&存储条件

分子量 284.36
分子式 C9H12N6OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(7-imino-3-propyl-2-thioxo-3,7-dihydrothiazolo[4,5-d]pyrimidin-6(2H)-yl)urea

参考文献

1. Kumari N, et al. Neurosci Lett. 2017 Apr 24;647:53-60.

2. Kumari N, et al. Neurosci Lett. 2018 May 14;675:74-82.

3. Luthra PM, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1214-8.

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