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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-IDOR-1136-517
IDOR-1136-517

Chemical Structure : IDOR-1136-517

CAS No.: 3042814-69-4

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IDOR-1136-517

货号: PC-24077Not For Human Use, Lab Use Only.

IDOR-1136-5177 is a highly potent, selective CCR8 antagonist with IC50 of 2 nM (hCCR8).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IDOR-1136-5177 is a highly potent, selective CCR8 antagonist with IC50 of 2 nM (hCCR8).
IDOR-1136-5177 potently inhibits the CCR8 receptor of the macaque and the dog (IC50=5/4 nM) but is inactive against mouse and rat CCR8.

物理化学性质&存储条件

分子量 390.51
分子式 C18H26N6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(cis-3-(2-amino-6-(isopropylamino)pyrimidin-4-yl)cyclobutyl)-5,6-dimethylpyridine-3 sulfonamide

参考文献

1. Diethelm S, et al. ChemMedChem. 2025 Feb 23:e202400968.

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