IDOR-1117-2520

Chemical Structure : IDOR-1117-2520

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货号: PC-22322Not For Human Use, Lab Use Only.

IDOR-1117-2520 is a potent, selective CCR6 antagonist with IC50 of 62.9 nM for CCL20-mediated calcium flow inhibition in FLIPR calcium mobilization assay.

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生物&药学活性

IDOR-1117-2520 is a potent, selective CCR6 antagonist with IC50 of 62.9 nM for CCL20-mediated calcium flow inhibition in FLIPR calcium mobilization assay.
IDOR-1117-2520 shows no inhibitory activity at 10 μM for any of the tested related chemokine receptors (CCR5, CCR7, CCR8, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR6).
IDOR-1117-2520 has IC50 of 20 nM in functional assay of receptor internalization (RI) performed in human whole blood.
IDOR-1117-2520 inhibits β-arrestin recruitment to human CCR6 induced by the addition of CCL20.
IDOR-1117-2520 (50 nM) inhibited cell migration toward CCL20 by 40 and 50% of the maximal migration for B cells and T cells, respectively.

物理化学性质&存储条件

分子量	436.56
分子式	C25H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)propan-2-ol

参考文献

1. Meyer EA, et al. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00186.

IDOR-1117-2520

生物&药学活性

物理化学性质&存储条件

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IDOR-1117-2520

生物&药学活性

物理化学性质&存储条件

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