IDO2 inhibitor 22

Chemical Structure : IDO2 inhibitor 22

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货号: PC-23332Not For Human Use, Lab Use Only.

IDO2 inhibitor 22 is a selective iIndoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with IC50 of 112 nM and 411 nM for IDO2 and IDO1 respectively.

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200 mg		Get quote

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生物&药学活性

IDO2 inhibitor 22 is a selective indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with IC50 of 112 nM and 411 nM for IDO2 and IDO1 respectively.
IDO2 inhibitor 22 alleviated disease severity and reduced inflammatory cytokines in both the collagen-induced arthritis (CIA) mice model and adjuvant arthritis (AA) rat model.

物理化学性质&存储条件

分子量	541.37
分子式	C21H21BrN10O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-((1-(2-((4-(N-(3-Bromobenzyl)-N'-hydroxycarbamimidoyl)-1,2,5-oxadiazol-3-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)picolinamide

参考文献

1. He G, et al. J Med Chem. 2022 Nov 10;65(21):14348-14365.