IDN-7314 | pan-Caspase inhibitor | Probechem Biochemicals

Chemical Structure : IDN-7314

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IDN-7314 (IDN7314, IDN 7314)

货号: PC-61354Not For Human Use, Lab Use Only.

IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.

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生物&药学活性

IDN-7314 is a potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
IDN-7314 also potently inhibited Fas-induced apoptosis of Jurkat cells with IC50 of 6.3 nM, demonstrates protective activity in the mouse model of Fas-induced hepatitis (ED50=0.7mg/kg, p.o.).
IDN-7314 synergistically inhibits tumor growth by activation of necroptosis and increased secretion of TNFα in a model of colon carcinoma combined with 5-FU.

物理化学性质&存储条件

分子量	549.382
分子式	C22H17F6N3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((S)-2-(2-((2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

参考文献

1. Oliver Metzig M, et al. Oncogene. 2016 Jun 30;35(26):3399-409.

2. Ueno H, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):199-202.

IDN-7314 (IDN7314, IDN 7314)

生物&药学活性

物理化学性质&存储条件

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IDN-7314 (IDN7314, IDN 7314)

生物&药学活性

物理化学性质&存储条件

参考文献

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