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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-IDI-6273
IDI-6273

Chemical Structure : IDI-6273

CAS No.: 433945-73-4

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IDI-6273 (IDI6273)

货号: PC-70339Not For Human Use, Lab Use Only.

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
    IDI-6273 displays 10.95-fold more active against 3D7 E182D than 3D7.
    IDI-6273 does not yield resistant parasites with a combination of Genz-669178.

    物理化学性质&存储条件

    分子量 341.835
    分子式 C20H20ClNO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one

    参考文献

    1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804.

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