ICeD-2 | DPP9 inhibitor | Probechem Biochemicals

Chemical Structure : ICeD-2

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ICeD-2 (inducer of cell death-2)

货号: PC-49297Not For Human Use, Lab Use Only.

ICeD-2 is a potent dipeptidyl peptidase 9 (DPP9) inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.

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生物&药学活性

ICeD-2 is a potent dipeptidyl peptidase 9 (DPP9) inhibitor capable of killing HIV-1 infected peripheral blood mononuclear cells, activates the caspase recruitment domain family member 8 (CARD8) inflammasome.
The efficacy of ICeD-2 is dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells.
ICeD-2 lowers the efficacious cell kill concentration of efavirenz to a clinically relevant dose at concentrations that do not result in complete DPP9 inhibition.

物理化学性质&存储条件

分子量	327.472
分子式	C20H29N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanone, 2-amino-1-(1,3-dihydro-2H-isoindol-2-yl)-2-[trans-4-(1-pyrrolidinyl)cyclohexyl]-, (2S)-

参考文献

1. Moore KP, et al. ACS Chem Biol. 2022 Aug 31. doi: 10.1021/acschembio.2c00515.

ICeD-2 (inducer of cell death-2)

生物&药学活性

物理化学性质&存储条件

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ICeD-2 (inducer of cell death-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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