ICT12035 | FPR1 antagonist | Probechem Biochemicals

Chemical Structure : ICT12035

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ICT12035 (AZ2158, AZ-2158, ICT-12035)

货号: PC-72082Not For Human Use, Lab Use Only.

ICT12035 (AZ2158) is a potent, selective formylpeptide receptor-1 (FPR1) antagonist with IC50 of 30 nM in calcium mobilisation assays (100 nM fMLF).

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生物&药学活性

ICT12035 (AZ2158) is a potent, selective formylpeptide receptor-1 (FPR1) antagonist with IC50 of 30 nM in calcium mobilisation assays (100 nM fMLF).
ICT12035 is selective (> 100 fold versus FPR2), and non-cytotoxic (cell viability above 95 ± 5% at 100 uM).
ICT12035 reduces fMLF-induced increases in proliferation in in U87-MG cells, which is a more potent agonist of FPR1 than ANXA1.
ICT12035 modulates growth of U87-MG xenotransplanted tumour in mice.

物理化学性质&存储条件

分子量	490.663
分子式	C25H38N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-3,3-dimethylbutan-2-yl)-1-((1s,4R)-4-methoxycyclohexyl)-3-methyl-5-((4-methylphenyl)sulfonamido)-1H-pyrazole-4-carboxamide

参考文献

1. Djevdet S Ahmet, et al. Sci Rep. 2020 Oct 14;10(1):17249.

ICT12035 (AZ2158, AZ-2158, ICT-12035)

生物&药学活性

物理化学性质&存储条件

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ICT12035 (AZ2158, AZ-2158, ICT-12035)

生物&药学活性

物理化学性质&存储条件

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