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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-ICEC 0942 hydrochloride
ICEC 0942 hydrochloride

Chemical Structure : ICEC 0942 hydrochloride

CAS No.: 1805789-54-1

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ICEC 0942 hydrochloride (Samuraciclib hydrochloride, CT7001 hydrochloride)

货号: PC-35095Not For Human Use, Lab Use Only.

ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
ICEC0942 displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9.
ICEC0942 demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM.
ICEC0942 shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.

物理化学性质&存储条件

分子量 430.981
分子式 C22H31ClN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol hydrochloride

参考文献

1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.

2. Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.

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