欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-ICCB280
ICCB280

Chemical Structure : ICCB280

CAS No.: 2041072-41-5

加入收藏

ICCB280 (ICCB-280)

货号: PC-27194Not For Human Use, Lab Use Only.

ICCB280 is a specific small molecule C/EBPalpha (C/EBPα) agonist, induces myeloid differentiation of leukemia cell lines by increasing expression of C/EBPα and C/EBPε, and decreasing expression of c-Myc.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ICCB280 is a specific small molecule C/EBPalpha (C/EBPα) agonist, induces myeloid differentiation of leukemia cell lines by increasing expression of C/EBPα and C/EBPε, and decreasing expression of c-Myc.
ICCB280 suppresses HL-60 cell growth with IC50 of 8.6 uM (48 hours).
ICCB280 (10 uM) induces upregulation of C/EBPα and C/EBPε, modulates C/EBPα target genes, but not C/EBPβ.
ICCB280 induces differentiation and apoptosis in primary blast cells from AML patients.
ICCB280 and G-CSF cooperatively induce granulocytic differentiation.

物理化学性质&存储条件

分子量 386.41
分子式 C23H18N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-(3,4-Dihydroxystyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one

参考文献

1. Sridhar R, et, al. Molecules. 2018 Aug 3;23(8):1938

2. Radomska HS, et, al. J Biomol Screen. 2015 Oct;20(9):1150-9.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: