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首页-小分子抑制剂&激动剂-Others-Other Targets-ICCB-19
ICCB-19

Chemical Structure : ICCB-19

CAS No.: 750621-52-4

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ICCB-19 (ICCB19)

货号: PC-38287Not For Human Use, Lab Use Only.

ICCB-19 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ICCB-19 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
TRADD-N interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
ICCB-19 indirectly inhibited RIPK1, inhibited (bortezomib)-induced apoptosis and RDA with IC50 of 1 uM.
ICCB-19 effectively induced autophagy and the degradation of long-lived proteins.
Inhibition of TRADD by ICCB-19 or Apt-1 (Apostatin-1, Cat. PC-38288) blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.

物理化学性质&存储条件

分子量 255.38
分子式 C12H21N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-cycloheptyl-2-((4,5-dihydro-1H-imidazol-2-yl)thio)acetamide

参考文献

1. Daichao Xu, et al. Nature. 2020 Nov;587(7832):133-138.

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