ICA604025 | Nav1.9 inhibitor | Probechem Biochemicals

Chemical Structure : ICA604025

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ICA604025 (ICA-604025)

货号: PC-26899Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

ICA604025 is a potent, selective sodium channel Nav1.9 subtype inhibitor, inhibits human Nav1.9 in a state dependent manner with EC50s of 9 nM and 1.1 μM for the activated/inactivated state versus resting closed state.
ICA604025 exhibits a similar potency for inhibition of cynomolgus monkey Nav1.9 but ∼50-fold lower potency for inhibition of rodent Nav1.9.
ICA604025 is a 300- to 1800-fold more potent inhibitor of human Nav1.9 compared with other human Nav1.x family members.
Nav1.9 is a voltage-gated sodium channel genetically associated with human pain disorders and thus is a key target for new analgesics.

物理化学性质&存储条件

分子量	378.30
分子式	C16H15F5N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2,2-difluoroethyl)-4-(7-(trifluoromethyl) benzofuran-2-yl) morpholine-2-carboxamide

参考文献

1. Potet F, et al. Mol Pharmacol. 2026 May 5;108(5-6):100125.

ICA604025 (ICA-604025)

生物&药学活性

物理化学性质&存储条件

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ICA604025 (ICA-604025)

生物&药学活性

物理化学性质&存储条件

参考文献

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