ICA135 |CAS:825601-94-3 Probechem Biochemicals

Chemical Structure : ICA135

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ICA135 (ICA-135;ICA 135)

货号: PC-36019Not For Human Use, Lab Use Only.

ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM.

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生物&药学活性

ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM.
ICA135 exerts protective function in vivo in an established mouse model of CV-A10.
ICA135 exhibits inhibitory effect on Enteroviruses four species A-D with IC50 of 0.566 and 9.68 uM, including EV-A71 and CV-A16 from specie A, CV-B3 from specie B, PV-1 from specie C, and EV-D68 from specie D。
ICA135 binds to the VP1 hydrophobic pockets with high-binding affinity.

物理化学性质&存储条件

分子量	482.58
分子式	C30H30N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dimethoxyphenyl)-3-(1-(2-hydroxy-3-(indolin-1-yl)propyl)-1H-indol-3-yl)prop-2-en-1-one

参考文献

1. Chen J, et al. Cell Discov. 2019 Jan 15;5:4. doi: 10.1038/s41421-018-0073-7.

ICA135 (ICA-135;ICA 135)

生物&药学活性

物理化学性质&存储条件

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ICA135 (ICA-135;ICA 135)

生物&药学活性

物理化学性质&存储条件

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