ICA-27243 |CAS:325457-89-4 Probechem Biochemicals

Chemical Structure : ICA-27243

CAS No.: 325457-89-4

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ICA-27243 (ICA27243;ICA-027243)

货号: PC-60824Not For Human Use, Lab Use Only.

ICA-27243 (ICA-207243) is a potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

ICA-27243 (ICA-207243) is a potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.

ICA-27243 enhances both (86)Rb(+) efflux (EC50= 0.2 microM) and whole-cell currents in CHO cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50= 0.4 microM).

ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5 and is selective over a wide range of neurotransmitter receptors and ion channels such as voltage-dependent sodium channels and GABA-gated chloride channels.

ICA-27243 (1-10 microM) reversibly suppresses seizure-like activity in an ex vivo hippocampal slice model of epilepsy and demonstrates in vivo anticonvulsant activity (ED(50) = 8.4 mg/kg) in the mouse maximal electroshock epilepsy model.

物理化学性质&存储条件

分子量	268.648
分子式	C12H7ClF2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide

参考文献

1. Amato G, et al. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

ICA-27243 (ICA27243;ICA-027243)

生物&药学活性

物理化学性质&存储条件

参考文献

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ICA-27243 (ICA27243;ICA-027243)

生物&药学活性

物理化学性质&存储条件

参考文献

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