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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA-PK-IC 87361
IC 87361

Chemical Structure : IC 87361

CAS No.: 404011-02-5

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IC 87361 (IC87361, IC-87361)

货号: PC-62995Not For Human Use, Lab Use Only.

IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β.
    IC 87361 enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.

    物理化学性质&存储条件

    分子量 323.348
    分子式 C19H17NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-hydroxy-7-morpholino-2-phenyl-4H-chromen-4-one

    参考文献

    1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.

    2. Shinohara ET, et al. Cancer Res. 2005 Jun 15;65(12):4987-92.

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