IC-9564 |CAS:174847-98-4 Probechem Biochemicals

Chemical Structure : IC-9564

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IC-9564 (IC9564;AIDS033640)

货号: PC-62902Not For Human Use, Lab Use Only.

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain.

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生物&药学活性

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain.
IC-9564 also has IC90s of >5, 2.65, and 1.84 uM for DH012, QZ4734, and HIV-1 89.6, respectively.
HIV-1 gp120 plays a key role in the anti-HIV-1 activity of IC9564.

物理化学性质&存储条件

分子量	755.138
分子式	C46H78N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-3-Hydroxy-4-[[8-[[(3β)-3-hydroxy-28-oxolup-20(29)-en-28-yl]amino]-1-oxooctyl]amino]-6-methylheptanoic acid

参考文献

1. Holz-Smith SL, et al. Antimicrob Agents Chemother. 2001 Jan;45(1):60-6.

2. Narumi T, et al. Bioorg Med Chem. 2013 May 1;21(9):2518-26.

3. Sun IC, et al. J Med Chem. 2002 Sep 12;45(19):4271-5.

IC-9564 (IC9564;AIDS033640)

生物&药学活性

物理化学性质&存储条件

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IC-9564 (IC9564;AIDS033640)

生物&药学活性

物理化学性质&存储条件

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