欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -IBR2
IBR2

Chemical Structure : IBR2

CAS No.: 313526-24-8

加入收藏

IBR2 (RAD51 inhibitor IBR2)

货号: PC-62970Not For Human Use, Lab Use Only.

IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.
IBR2 disrupts RAD51 multimerization and inhibits RAD51-mediated HR repair, reduces RAD51 protein levels via proteasome-mediated degradation.
IBR2 inhibits cell growth and induces apoptosis in imatinib-resistant T315I-Ba/F3 cells。
IBR2 significantly prolongs animal survival in a murine imatinib-resistant CML model bearing the T315I Bcr-abl mutation.

物理化学性质&存储条件

分子量 400.496
分子式 C24H20N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline

参考文献

1. Zhu J, et al. EMBO Mol Med. 2013 Mar;5(3):353-65.

2. Ferguson PJ, et al. J Pharmacol Exp Ther. 2017 Oct 23. pii: jpet.117.241661.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: