IBMX (Isobutylmethylxanthine) | PDEs inhibitor | Probechem Biochemicals

Chemical Structure : IBMX

CAS No.: 28822-58-4

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IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960)

货号: PC-42971Not For Human Use, Lab Use Only.

IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960) is a broad-spectrum inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50 of 5-50 uM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11.

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100 mg	￥850	In stock
250 mg	￥1350	In stock
500 mg	￥1850	In stock
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生物&药学活性

IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960) is a broad-spectrum inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50 of 5-50 uM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11.
IBMX is insensitive to PDE8A, PDE8B, and PDE9; increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases.

物理化学性质&存储条件

分子量	222.2438
分子式	C10H14N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-

参考文献

1. Snyder SH, et al. Proc Natl Acad Sci U S A. 1981 May;78(5):3260-4.

2. Kawabata A, et al. Thromb Res. 2001 Mar 15;101(6):513-5.

3. Tio M, et al. PLoS One. 2010 Feb 24;5(2):e9398.

4. Wu BN, et al. Br J Pharmacol. 2004 Aug;142(7):1105-14.

IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960)

生物&药学活性

物理化学性质&存储条件

参考文献

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IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960)

生物&药学活性

物理化学性质&存储条件

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