IB15C

Chemical Structure : IB15C

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货号: PC-27375Not For Human Use, Lab Use Only.

IB15C is a small molecule binder targeting the inhibitory immune receptor ILT3 (LILRB4, CD85k) with MST Kd of 0.92 uM, potently inhibits the ILT3-ApoE interaction with IC50 of 0.48 uM in ELISA-based competition assays.

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生物&药学活性

IB15C is a small molecule binder targeting the inhibitory immune receptor ILT3 (LILRB4, CD85k) with MST Kd of 0.92 uM, potently inhibits the ILT3-ApoE interaction with IC50 of 0.48 uM in ELISA-based competition assays.
IB15C produces a robust concentration-dependent reduction in binding signal, with an IC50 of 0.64 uM in BLI assays.
IB15C disrupts ILT3-ApoE complex formation rather than indirectly altering assay components or protein stability.
IB15C (1-10 uM) reduced SHP1 and SHP2 phosphorylation in a concentration-dependent manner.
IB15C suppresses ILT3-dependent signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia.
IB15C attenuates NF-κB activation, significantly reduces IL-1β secretion and restores Aβ internalization.

物理化学性质&存储条件

分子量	383.45
分子式	C21H25N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(3,4-dimethoxyphenyl)propyl)-3-isopropylisoxazolo[5,4-b]pyridine-5-carboxamide

参考文献

1. Abdel-Rahman SA, et al. ACS Med Chem Lett. 2026 Jun 18;17(7):1647-1654.

IB15C

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IB15C

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