Chemical Structure : IAXO-102
CAS No.: 1115270-63-7
货号: PC-63208Not For Human Use, Lab Use Only.
IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥1980 | In stock | |
10 mg | ¥3280 | In stock | |
25 mg | ¥5280 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development.
IAXO-102 inhibits MAPK and p65 NF-kB phosphorylation associated with down regulation of the expression of TLR4 and TLR4 dependent proinflammatory proteins.
IAXO-102 decreases Angiotensin II-induced aortic expansion, rupture and incidence of abdominal aortic aneurysm (AAA).
分子量 | 585.955 | |
分子式 | C35H71NO5 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-a-D-glucopyranoside |
1. Huggins C, et al. Atherosclerosis. 2015 Oct;242(2):563-70.
2. Kawakita F, et al. Mol Neurobiol. 2017 Oct;54(8):6624-6633.
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