IACS-52825 | DLK inhibitor | Probechem Biochemicals

Chemical Structure : IACS-52825

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IACS-52825 (IACS52825, IACS 52825)

货号: PC-20983Not For Human Use, Lab Use Only.

IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.

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生物&药学活性

IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays.
IACS-52825 shows no significant inhibition of the hERG channel or CYP P450 enzymes and no significant activities against an 80-member Eurofins CEREP panel of various ion channels and receptors or a 403-member Eurofins DiscoverX kinase panel.
IACS-52825 (orally once daily at 3, 10, or 30 mg/kg) dose-dependently reverses cisplatin-induced mechanical allodynia.

物理化学性质&存储条件

分子量	426.29
分子式	C16H13F7N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(4-(6-Amino-5-(trifluoromethoxy)pyridin-3-yl)-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-imidazol-2-yl)-2,2,2-trifluoroethanol

参考文献

1. Kang Le, et al. J Med Chem. 2023 Jul 12. doi: 10.1021/acs.jmedchem.3c00788.

IACS-52825 (IACS52825, IACS 52825)

生物&药学活性

物理化学性质&存储条件

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IACS-52825 (IACS52825, IACS 52825)

生物&药学活性

物理化学性质&存储条件

参考文献

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