I194496 | CSE inhibitor | Probechem Biochemicals

Chemical Structure : I194496

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I194496 (I 194496)

货号: PC-72156Not For Human Use, Lab Use Only.

I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.

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生物&药学活性

I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.
I194496 suppressed CSE/H2S system of TNBC cells, significantly inhibited production of H2S in MDA-MB-231 and MDA-MB-468 cells, significantly decreased the protein and mRNA levels of CSE in MDA-MB-231 and MDA-MB-468 cells, but did not affect the expression of CBS protein.
I194496 inhibits the growth, proliferation, migration and invasion of TNBC cells, blocks the PI3K/Akt and Ras/Raf/ERK signaling pathways.
I194496 inhibits the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways in human TNBC cells.
I194496 inhibits human TNBC xenograft tumors in nude mice.

物理化学性质&存储条件

分子量	579.579
分子式	C28H23F2N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (5.8 mg/mL)
Chemical Name/SMILES	7-(difluoromethyl)-N-{4-[(2-methoxyanilino) sulfonyl]phenyl}-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

参考文献

1. Ya Liu, et al. Sci Rep. 2021 Apr 26;11(1):8963.

I194496 (I 194496)

生物&药学活性

物理化学性质&存储条件

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I194496 (I 194496)

生物&药学活性

物理化学性质&存储条件

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