I-BET787 | BET inhibitor | Probechem Biochemicals

Chemical Structure : I-BET787

加入收藏

I-BET787 (GSK3535787, GSK 3535787)

货号: PC-22527Not For Human Use, Lab Use Only.

I-BET787 (GSK3535787) is potent, efficient pan-BET bromodomain inhibitor with pIC50 of 7.1/5.9 for BRD4 BD1/BD2, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

I-BET787 (GSK3535787) is potent, efficient pan-BET bromodomain inhibitor with pIC50 of 7.1/5.9 for BRD4 BD1/BD2, respectively.
I-BET787 (GSK3535787) demonstrates >500-fold selectivity over 26 bromodomains tested, apart from BAZ2A (20–40-fold) and CREBBP/EP300 (80–160-fold).
I-BET787 (GSK3535787) inhibits human whole blood MCP-1 with an pIC50 value of 6.9, inhibits LPS-stimulated hWB IL-6 with pIC50 of 6.5.
I-BET787 (GSK3535787) demonstrates efficacy in a mouse model of inflammation and suitable properties for both oral and intravenous (IV) administration.

物理化学性质&存储条件

分子量	321.81
分子式	C16H20ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-Chloro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazole-2-yl)-1,3-dimethylpyridin-2(1H)-one

参考文献

1. David J Hirst, et al. J Med Chem. 2024 Jun 12. doi: 10.1021/acs.jmedchem.4c00959.

I-BET787 (GSK3535787, GSK 3535787)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

I-BET787 (GSK3535787, GSK 3535787)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.