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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-I-BET567
I-BET567

Chemical Structure : I-BET567

CAS No.: 1887237-54-8

I-BET567 (GSK3383567, I-BET 567)

货号: PC-72646Not For Human Use, Lab Use Only.

I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT.
I-BET567 (GSK3383567) effectively inhibited the proliferation of human NMC cell line 11060 in vitro with mean IC50 of 0.63 uM.
I-BET567 (30 mg/kg) demonstrated tumor growth inhibition in the mouse NMC xenograft model.

物理化学性质&存储条件

分子量 359.814
分子式 C17H18ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide

参考文献

1. Philip G Humphreys, et al. J Med Chem. 2022 Feb 10;65(3):2262-2287.

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