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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-I-BET469
I-BET469

Chemical Structure : I-BET469

CAS No.: 2003197-53-1

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I-BET469

货号: PC-22528Not For Human Use, Lab Use Only.

I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.
I-BET469 inhibits human whole blood MCP-1 with an pIC50 value of 7.6, inhibits LPS-stimulated hWB IL-6 with pIC50 of 7.7.

物理化学性质&存储条件

分子量 426.52
分子式 C23H30N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(1-(1,3-Dimethoxypropan-2-yl)-5-morpholino-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one

参考文献

1. Christopher R Wellaway, et al. J Med Chem. 2020 Jan 23;63(2):714-746.

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