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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-I-BET282E
I-BET282E

Chemical Structure : I-BET282E

CAS No.: 2885162-99-0

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I-BET282E (I-BET282 mesylate)

货号: PC-20161Not For Human Use, Lab Use Only.

I-BET282E (I-BET282 mesylate) is the mesylate salt of I-BET282, I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    I-BET282E (I-BET282 mesylate) is the mesylate salt of I-BET282 (Cat# PC-20162), I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins.
    I-BET282E (I-BET282 mesylate) (3 mg/kg, p.o.) shows in vivo efficacy in the rat collagen-induced arthritis (CIA) model.

    物理化学性质&存储条件

    分子量 546.64
    分子式 C26H34N4O7S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole methanesulfonate

    参考文献

    1. Katherine L Jones, et al. J Med Chem. 2021 Aug 26;64(16):12200-12227.

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