HypoxyStat

Chemical Structure : HypoxyStat

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货号: PC-24293Not For Human Use, Lab Use Only.

HypoxyStat is a small molecule that increase oxygen-hemoglobin binding affinity cause tissue hypoxia, binds hemoglobin, induces systemic hypoxia in mice breathing normoxic (21% O2) air.

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生物&药学活性

HypoxyStat is a small molecule that increase oxygen-hemoglobin binding affinity cause tissue hypoxia, binds hemoglobin, induces systemic hypoxia in mice breathing normoxic (21% O2) air.
HypoxyStat results in tissue hypoxia that is comparable to therapeutic inhaled hypoxia.
HypoxyStat improves survival and outcomes of Ndufs4 KO model of Leigh syndrome.
HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome.
HypoxyStat reverses very late stage of disease (∼P50) in Ndufs4 KO mice.

物理化学性质&存储条件

分子量	367.40
分子式	C21H21NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[(2S)-1-(2-Formylbenzoyl)-2-piperidinyl]methoxy]-6-hydroxybenzaldehyde

参考文献

1. Blume SY, et al. Cell. 2025 Feb 12:S0092-8674(25)00098-4.

HypoxyStat

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物理化学性质&存储条件

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HypoxyStat

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物理化学性质&存储条件

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