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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -Hycanthone
Hycanthone

Chemical Structure : Hycanthone

CAS No.: 3105-97-3

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Hycanthone

货号: PC-21907Not For Human Use, Lab Use Only.

Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM.
Hycanthone shows direct protein binding for APE1 with Kd of 10 nM.
Hycanthone is a bioactive metabolite of Lucanthone (Cat# PC-60602).

物理化学性质&存储条件

分子量 340.49
分子式 C20H24N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one

参考文献

1. Radin DP, J Pharmacol Exp Ther. 2024 Jan 31:JPET-AR-2023-002021.

2. Naidu MD, et al. PLoS One. 2011;6(9):e23679.

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