Hv1 inhibitor HIF

Chemical Structure : Hv1 inhibitor HIF

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货号: PC-72018Not For Human Use, Lab Use Only.

Hv1 inhibitor HIF is a novel inhibitor of the voltage-gated proton channel Hv1 interacts with the Hv1 VSD in the up and down states.

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生物&药学活性

Hv1 inhibitor HIF is a novel inhibitor of the voltage-gated proton channel Hv1 interacts with the Hv1 VSD in the up and down states.
HIF rapidly inhibits proton conduction in the up state by blocking the open channel.
HIF interacts with a second site that is accessible in the down state and is responsible for key features of HIF-mediated inhibition, such as the slow component of current decay and the slow recovery from inhibition.
The voltage-gated proton channel Hv1 plays important roles in numerous biological processes, including pH homeostasis, the immune response, and sperm cell function.
Hv1 channel belongs to the large family of proteins containing voltage-sensing domains (VSDs), which also includes Nav, Kv, and Cav channels and voltage-sensitive phosphatases.

物理化学性质&存储条件

分子量	265.264
分子式	C13H13F2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-amino-5-methyl-1H-imidazol-4-yl)-1-(3,5-difluorophenyl)propan-1-one

参考文献

1. Chang Zhao, et al. J Gen Physiol. 2021 Sep 6;153(9):e202012833.