HuR inhibitor KH-3

Chemical Structure : HuR inhibitor KH-3

CAS No.: 1215115-03-9

加入收藏

货号: PC-72480Not For Human Use, Lab Use Only.

HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.
KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.
KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.
KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.
Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.

物理化学性质&存储条件

分子量	430.537
分子式	C21H22N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(5-((4-(tert-butyl)phenyl)sulfonamido)benzo[b]thiophen-2-yl)-N-hydroxyacrylamide

参考文献

1. Xiaoqing Wu, et al. Commun Biol. 2020 Apr 24;3(1):193.

2. Simeng Liu, et al. Clin Sci (Lond). 2020 Jun 26;134(12):1433-1448.