Hsp90α inhibitor A17 | Hsp90α/p23 inhibitor | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-Hsp90α inhibitor A17

Chemical Structure : Hsp90α inhibitor A17

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Hsp90α inhibitor A17 (Hsp90α/p23 inhibitor A17)

货号: PC-70363Not For Human Use, Lab Use Only.

Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1.
A17 inhibits Hsp90(α/β)/p23 interactions and degrading Hsp90 client proteins in cell culture, but not in live mice.

物理化学性质&存储条件

分子量	384.333
分子式	C15H11F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide

参考文献

1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.

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Hsp90α inhibitor A17 (Hsp90α/p23 inhibitor A17)

生物&药学活性

物理化学性质&存储条件

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Hsp90α inhibitor A17 (Hsp90α/p23 inhibitor A17)

生物&药学活性

物理化学性质&存储条件

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