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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-Hsp90α-IN-12h
Hsp90α-IN-12h

Chemical Structure : Hsp90α-IN-12h

CAS No.: 2765823-81-0

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Hsp90α-IN-12h

货号: PC-72570Not For Human Use, Lab Use Only.

Hsp90α-IN-12h is the first Hsp90α-selective inhibitor with IC50 of 460 nM, exhibit 48-fold selectivity versus other Hsp90 isoforms.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Hsp90α-IN-12h is the first Hsp90α-selective inhibitor with IC50 of 460 nM, exhibit 48-fold selectivity versus other Hsp90 isoforms.
    In NCI-H522 cells, Hsp90a-dependent substrates are readily degraded in the presence of Hsp90a-selective inhibitor.

    物理化学性质&存储条件

    分子量 375.486
    分子式 C23H21NO2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-((3-ethylphenyl)thio)-4-hydroxyphenyl)(isoindolin-2-yl)methanone

    参考文献

    1. Sanket J Mishra, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551.

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