HlyU inhibitor CM14 (1025E12) |CAS:588678-13-1 Probechem Biochemicals

Chemical Structure : HlyU inhibitor CM14

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HlyU inhibitor CM14 (1025E12)

货号: PC-36127Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.
HlyU inhibitor CM14 (1025E12) reduces HlyU-dependent expression of virulence genes in V. vulnificus.
HlyU inhibitor CM14 (1025E12) decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death.
HlyU inhibitor CM14 (1025E12) also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.

物理化学性质&存储条件

分子量	345.372
分子式	C20H11NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide

参考文献

1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y.