Hispidulin | Pim-1 inhibitor, MNK2 inhibitor | Probechem Biochemicals

Chemical Structure : Hispidulin

CAS No.: 1447-88-7

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Hispidulin (Dinatin)

货号: PC-23346Not For Human Use, Lab Use Only.

Hispidulin (Dinatin) is a natural flavone with a broad spectrum of biological activities, inhibits Pim-1 and MNK2 with IC50 of 1.7 uM and 252 nM respectively, also inhibits COMT.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

Hispidulin (Dinatin) is a natural flavone with a broad spectrum of biological activities, inhibits Pim-1 and MNK2 with IC50 of 1.7 uM and 252 nM respectively, also inhibits COMT.
Hispidulin inhibited the growth of MOLM-13 and MV4-11 AML cells by downregulating eIF4E phosphorylation and arresting the cell cycle at the G0/G1 phase.
Hispidulin Hispidulin attenuated social withdrawal by activating D1 receptors indirectly through elevated dopamine levels in the PFC by COMT inhibition.
Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer.

物理化学性质&存储条件

分子量	300.27
分子式	C16H12O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one

参考文献

1. Chao SW, et al. J Nat Prod. 2015 Aug 28;78(8):1969-76.

2. Ferrándiz ML, et al. Life Sci. 1994;55(8):PL145-50.

3. Chen LC, et al. J Nat Prod. 2020 Oct 23;83(10):2967-2975.

4. Mouri A, et al. Br J Pharmacol. 2020 Jul;177(14):3210-3224.

Hispidulin (Dinatin)

生物&药学活性

物理化学性质&存储条件

参考文献

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Hispidulin (Dinatin)

生物&药学活性

物理化学性质&存储条件

参考文献

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