HgCht2 inhibitor 1516b | HgCht2 inhibitor | Probechem Biochemicals

Chemical Structure : HgCht2 inhibitor 1516b

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HgCht2 inhibitor 1516b (Hg-CHI-1)

货号: PC-22580Not For Human Use, Lab Use Only.

HgCht2 inhibitor 1516b is a specific, substrate competitive small molecule cyst nematodes chitinase HgCht2 ( Hg-CHI-1) inhibitor, inhibits the hydrolytic activity of HgCht2 with Kd of 3.3 uM.

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生物&药学活性

HgCht2 inhibitor 1516b is a specific, substrate competitive small molecule cyst nematodes chitinase HgCht2 ( Hg-CHI-1) inhibitor, inhibits the hydrolytic activity of HgCht2 with Kd of 3.3 uM.
HgCht2 inhibitor 1516b does not inhibit the activity of two plant GH18 chitinases: MtNFH from Medicago truncatula.
HgCht2 inhibitor 1516b binds to the substrate-binding cleft in a binding mode similar to that of SmNF-V in HgCht2.
HgCht2 inhibitor 1516b successfully suppresses the antagonism of cyst nematodes towards nitrogen-fixing rhizobia and phosphorus-absorbing arbuscular mycorrhizal symbioses.
HgCht2 inhibitor 1516b has a potential application in rescuing beneficial microorganism symbioses under nematode-infested conditions.

物理化学性质&存储条件

分子量	424.50
分子式	C26H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-(1H-indol-3-yl)ethyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

参考文献

1. Chen W, et al. Nat Microbiol. 2024 Jun 17. doi: 10.1038/s41564-024-01727-5.

HgCht2 inhibitor 1516b (Hg-CHI-1)

生物&药学活性

物理化学性质&存储条件

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HgCht2 inhibitor 1516b (Hg-CHI-1)

生物&药学活性

物理化学性质&存储条件

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