Hetrombopag | TPO receptor agonist | Probechem Biochemicals

Chemical Structure : Hetrombopag

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Hetrombopag (SHR-8735)

货号: PC-35778Not For Human Use, Lab Use Only.

Hetrombopag (SHR-8735) is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.

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生物&药学活性

Hetrombopag (SHR-8735) is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist.
Hetrombopag specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways.
Hetrombopag specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo.

物理化学性质&存储条件

分子量	458.474
分子式	C25H22N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(5E)-5-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]furan-2-carboxylic acid

参考文献

1. Zhou N, et al. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577.

2. Xie C, et al. J Cell Mol Med. 2018 Nov;22(11):5367-5377.

Hetrombopag (SHR-8735)

生物&药学活性

物理化学性质&存储条件

参考文献

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Hetrombopag (SHR-8735)

生物&药学活性

物理化学性质&存储条件

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