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首页-小分子抑制剂&激动剂-Others-Other Targets-Herbacetin
Herbacetin

Chemical Structure : Herbacetin

CAS No.: 527-95-7

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Herbacetin

货号: PC-28349Not For Human Use, Lab Use Only.

Herbacetin is a naturally occurring flavonoid and potent, specific, allosteric ornithine decarboxylase (ODC) inhibitor, exhibits potent anticancer activity in colon cancer cell lines expressing high levels of ODC.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Herbacetin is a naturally occurring flavonoid and potent, specific, allosteric ornithine decarboxylase (ODC) inhibitor, exhibits potent anticancer activity in colon cancer cell lines expressing high levels of ODC.
Herbacetin effectively suppresses HCT116 xenograft tumor growth and also reduced the number and size of polyps in a mouse model of APC-driven colon cancer (ApcMin/+).
Herbacetin also shows anti-fibrotic agent and exerts its anti-fibrotic effect on pulmonary and renal fibrosis by targeting TGFBR2 for degradation.
Herbacetin inhibits the polyamine biosynthetic pathway and targets the methyltransferase (MTase) enzyme of both the dengue virus (DENV) and chikungunya virus (CHIKV), GTP binding site in the DENV-3 NS5 MTase with Ki of 0.43 uM.
Herbacetin mitigates oxidative stress and ferroptosis to protect against doxorubicin-induced cardiotoxicity.
Herbacetin is capable of restoring immune balance in VKH disease by suppressing pathogenic T cell responses.

物理化学性质&存储条件

分子量 302.24
分子式 C15H10O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

参考文献

1. Li H, et al. Sci Adv. 2026 Sep 18;12(38):eaea6376.

2. Kim DJ, et al. Cancer Res. 2016 Mar 1;76(5):1146-1157.

3. Liao F, et al. Mol Ther. 2026 Aug 5;34(8):4903-4920.

4. Yang H, et al. Biochem Pharmacol. 2025 Oct;240:117117.

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