Helenalin | p65 inhibitor | Probechem Biochemicals

Chemical Structure : Helenalin

加入收藏

Helenalin (NSC 85236)

货号: PC-62417Not For Human Use, Lab Use Only.

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.

规格	价格	库存	数量
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
Helenalin ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM).
Helenalin suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.

物理化学性质&存储条件

分子量	262.305
分子式	C15H18O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione

参考文献

1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20;12(1):102-113.

2. Chen S, et al. Cell Death Dis. 2017 Mar 30;8(3):e2710.

3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11;12:93.

Helenalin (NSC 85236)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Helenalin (NSC 85236)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.