Hederagenin

Chemical Structure : Hederagenin

CAS No.: 465-99-6

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货号: PC-23613Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥680	In stock
50 mg	￥980	In stock
100 mg	￥1480	In stock
250 mg		Get quote

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生物&药学活性

Hederagenin is a triterpenoid saponin with antitumor activity against multifarious cancers, is a selective antagonist of neuropeptide FF receptor 1 (NPFFR1), selectively inhibits activation of NPFFR1 by NPFF or NPVF through orthosteric antagonism.
Hederagenin inhibits the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation.
Hederagenin increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis.
Hederagenin inhibits mitochondrial damage in Parkinson's disease via mitophagy induction.

物理化学性质&存储条件

分子量	472.71
分子式	C30H48O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-Hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

参考文献

1. Lentschat H, et al. Angew Chem Int Ed Engl. 2024 Dec 6:e202417786.

2. Lu J, et al. Biochem Biophys Res Commun. 2024 Jul 23;718:150085.

Hederagenin

生物&药学活性

物理化学性质&存储条件

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Hederagenin

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