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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-Heclin
Heclin

Chemical Structure : Heclin

CAS No.: 890605-54-6

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Heclin

货号: PC-70324Not For Human Use, Lab Use Only.

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.

物理化学性质&存储条件

分子量 283.32
分子式 C17H17NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

参考文献

1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41.

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