HeE1-2Tyr

Chemical Structure : HeE1-2Tyr

CAS No.: 2245195-67-7

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货号: PC-24464Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HeE1-2Tyr is a potent, nonnucleoside inhibitor of flavivirus RNA dependent RNA polymerase (RdRp) with IC50 of 1.5 uM and 3.4 uM for DENV3 and WNV RdRps, respectively, also is a SARS-CoV-2 RdRp with IC50 of 27.6 uM.
HeE1-2Tyr inhibits an Ugandan strain of WNV with an IC50 = 2.1 uM, as well as all the four DENV serotypes, with IC50 ranging from 6.8 to 15 uM.
HeE1-2Tyr inhibits clinical strains of YFV with IC50 values ranging from 3.9 to 12 uM.
HeE1-2Tyr is a potent inhibitor of RdRp from Dengue virus (DENV), West Nile virus, and Yellow fever virus, all members of genus Flavivirus.

物理化学性质&存储条件

分子量	582.67
分子式	C33H30N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8-(Cyclohexyloxy)-1-oxo-2-phenyl-1H-benzo[4,5]thiazolo[3,2-a]pyridine-4-carbonyl)-L-tyrosine

参考文献

1. Kabinger F, et al. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2419854122.

2. Tarantino D, et al. Antiviral Res. 2016 Oct;134:226-235.

3. Dejmek M, et al. Viruses. 2021 Aug 11;13(8):1585.

HeE1-2Tyr

生物&药学活性

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