Harmine | Twist1 inhibitor | Probechem Biochemicals

Chemical Structure : Harmine

CAS No.: 442-51-3

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Harmine (Telepathine, Banisterine, Leucoharmine)

货号: PC-35649Not For Human Use, Lab Use Only.

规格	价格	库存
500 mg	￥580	In stock
1 g	￥880	In stock
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生物&药学活性

Harmine (Telepathine, Banisterine, Leucoharmine) is a fluorescent harmala alkaloid occurs in a number of different plants, reversibly inhibits monoamine oxidase A (MAO-A) but not MAO-B, also inhibits multiple Twist1 functions.
Harmine targeted the TWIST1 pathway through its promotion of TWIST1 protein degradation.
Harmine inhibits single-cell dissemination, suppression of normal branching in 3D epithelial culture, and proliferation of oncogene driver-defined NSCLC cells (IC50=22 uM).
Harmine also shows DYRK1A inhibitory activity, induces β-cell proliferation both in vitro and in vivo.

物理化学性质&存储条件

分子量	212.252
分子式	C13H12N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

参考文献

1. Spies M, et al. Transl Psychiatry. 2018 Sep 21;8(1):198.

2. Yochum ZA, et al. Oncogene. 2018 Aug 31. doi: 10.1038/s41388-018-0482-y.

3. Yochum ZA, et al. Mol Cancer Res. 2017 Dec;15(12):1764-1776.

4. Kumar K, et al. J Med Chem. 2018 Sep 13;61(17):7687-7699.

Harmine (Telepathine, Banisterine, Leucoharmine)

生物&药学活性

物理化学性质&存储条件

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Harmine (Telepathine, Banisterine, Leucoharmine)

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物理化学性质&存储条件

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