Hakin-1 | Hakai inhibitor | Probechem Biochemicals

Chemical Structure : Hakin-1

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Hakin-1 (Hakai inhibitor-1)

货号: PC-23887Not For Human Use, Lab Use Only.

Hakin-1 (Hakai inhibitor-1) is a specific small molecule inhibitor of the E3 ubiquitin-ligase Hakai, reduces Hakai-mediated total ubiquitination and Hakai-mediated ubiquitination of E-cadherin.

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生物&药学活性

Hakin-1 (Hakai inhibitor-1) is a specific small molecule inhibitor of the E3 ubiquitin-ligase Hakai, reduces Hakai-mediated total ubiquitination and Hakai-mediated ubiquitination of E-cadherin.
Hakin-1 strongly reduces the ubiquitination mediated by Hakai in a dose-dependent manner, does not affect ubiquitination when Hakai was not overexpressed.
Hakin-1 inhibits Hakai-mediated ubiquitination without affecting Hakai protein levels.
Hakin-1 induces cytotoxicity and an epithelial phenotype on epithelial tumour cell lines HT-29 and LoVo cells.
Hakin-1 increases the amount of E-cadherin levels at cell-cell contacts in HT-29 and LoVo cells, induces epithelial differentiation.
Hakin-1 reduces cell invasion and cell migration, and inhibits proliferation of epithelial tumour cells.
Hakin-1 inhibits tumour growth in Hakai-MDCK xenografted mice apparently without systemic toxicity.
Hakin-1 reduces N-cadherin mesenchymal markers in tumour xenografts and lung micrometastasis in vivo.

物理化学性质&存储条件

分子量	385.35
分子式	C16H11N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-{[2-(4-nitrophenyl)-2-oxoethyl]thio}-1H-tetrazol-1-yl)benzoic acid

参考文献

1. Martinez-Iglesias O, et al. Cancers (Basel). 2020 May 23;12(5):1340.

Hakin-1 (Hakai inhibitor-1)

生物&药学活性

物理化学性质&存储条件

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Hakin-1 (Hakai inhibitor-1)

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物理化学性质&存储条件

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