Chemical Structure : HZX-02-059
CAS No.: 2240205-30-3
货号: PC-47003Not For Human Use, Lab Use Only.
HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥1980 | In stock | |
10 mg | ¥2980 | In stock | |
25 mg | ¥4980 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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HZX-02-059 (Methuosis inducer 1) is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC.
HZX-02-059 exerts anti-proliferative action of DHL cells in a dose- and time-dependent manner, including Will-2, LR, and TMD8 cells (IC50=150-350 nM, 48 h).
HZX-02-059 induces a caspase-independent cell death in DHL cells. HZX-02-059 triggers non-apoptotic cell death of methuosis as a result of PIKfyve/TFEB inhibition.
HZX-02-059-induced cell cycle arrest is mechanistically associated with the inhibition of tubulin and mTOR/Myc axis.
HZX-02-059 (20 mg/kg, i.p.) suppresses growth of xenograft derived from DHL cells with a low systemic toxicity profile.
分子量 | 487.486 | |
分子式 | C27H20F3N5O | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(4-methyl-3-((6-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)phenyl)-3-(trifluoromethyl)benzamide |
1. Liying Feng, et al. Cell Death Discov. 2022 Jan 28;8(1):39.
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