HZS60 | NMDAR/TRPM4 inhibitor | Probechem Biochemicals

Chemical Structure : HZS60

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HZS60 (HZS-60)

货号: PC-23906Not For Human Use, Lab Use Only.

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生物&药学活性

HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons.
HZS60 at both 10 μM and 100 μM showed no effect on calcium-activated TRPM4 channel activity.
HZS60 boosted NMDAR-mediated downstream signaling in responses to NMDA treatment in primary neurons, inhibited OGD/R-induced decrease in phosphorylation of ERK, CREB, CaMKII, and Akt levels
HZS60 eliminated NMDA-induced mitochondrial dysfunction in primary neurons.
HZS60 (ig, 25 mg/kg) reduced neuronal damage in the penumbra of cerebral brain of mice after I/R injury.
HZS60 (ig, 25 mg/kg) disrupted the N/T interaction in mice after ischemic stroke.
HZS60 (ig, 25 mg/kg) treatment inhibited microglial activation in the MCAO-treated mice.

物理化学性质&存储条件

分子量	253.30
分子式	C13H17F2N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-((2-Aminoethyl)(ethyl)amino)ethyl)-2,4-difluorobenzonitrile

参考文献

1. Meiling Sun, et al. J Med Chem. 2025 Jan 2. doi: 10.1021/acs.jmedchem.4c02772.

HZS60 (HZS-60)

生物&药学活性

物理化学性质&存储条件

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HZS60 (HZS-60)

生物&药学活性

物理化学性质&存储条件

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