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HZ05

Chemical Structure : HZ05

CAS No.: 2097360-24-0

HZ05 (DHODH inhibitor HZ05)

货号: PC-63261Not For Human Use, Lab Use Only.

HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.

物理化学性质&存储条件

分子量 380.423
分子式 C21H21FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide

参考文献

1. Ladds MJGW, et al. Nat Commun. 2018 Mar 16;9(1):1107.

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