HZ-166 |CAS:612527-56-7 Probechem Biochemicals

Chemical Structure : HZ-166

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HZ-166 (HZ166)

货号: PC-35484Not For Human Use, Lab Use Only.

HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.

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生物&药学活性

HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors.
HZ-166 displays a statistically significant higher affinity for receptors not containing the α1 subunit with a rank order of α5 (Ki=140nM) > α2 (Ki=269 nM) > α1 (Ki=382 nM).
The Ki value of HZ166 for the α3β3γ2 combination (185± 47 nM) was statistically significantly lower than the Ki value observed for α1β3γ2 but not different from those of α2β3γ2 and α5β3γ2.
HZ-166 is antihyperalgesic in mouse models of inflammatory and neuropathic pain.

物理化学性质&存储条件

分子量	356.385
分子式	C21H16N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

参考文献

1. Fischer BD, et al. Neuropharmacology. 2010 Dec;59(7-8):612-8.

2. Di Lio A, et al. Neuropharmacology. 2011 Mar;60(4):626-32.

3. Witkin JM, et al. Neuropharmacology. 2018 Jul 15;137:332-343.

4. Rivas FM, et al. J Med Chem. 2009 Apr 9;52(7):1795-8.

HZ-166 (HZ166)

生物&药学活性

物理化学性质&存储条件

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HZ-166 (HZ166)

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