HZ-086 | A2AR inhibitor | Probechem Biochemicals

Chemical Structure : HZ-086

加入收藏

HZ-086 (HZ086)

货号: PC-24291Not For Human Use, Lab Use Only.

HZ-086 is a potent and selective inhibitor of adenosine A2A receptor (A2AR) with Ki of 1.4 nM (hA2A), >250-fold selective over A1R and A3R.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HZ-086 is a potent and selective inhibitor of adenosine A2A receptor (A2AR) with Ki of 1.4 nM (hA2A), >250-fold selective over A1R and A3R.
HZ-086 inhibits NECA (1 μM)-induced cAMP production in HEK-293T cells overexpressing A2AR with IC50 of 48 nM.
HZ-086 effectively reduced NECA-induced ERK phosphorylation in a dose-dependent manner.
HZ-086 abolishes immunosuppressive effects of adenosine in Jurkat T cells.
HZ-086 restores the T cell-mediated cytotoxicity suppressed by adenosine.
HZ-086 suppresses tumor growth and enhances the efficacy of PD-L1 inhibitor in colon cancer model.

物理化学性质&存储条件

分子量	440.51
分子式	C24H24N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(2-amino-6-(1-(1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)ethyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

参考文献

1. Wang P, et al. Eur J Pharmacol. 2025 Mar 19:177535.

HZ-086 (HZ086)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HZ-086 (HZ086)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.